Determination of Sitagliptin Phosphate in Bulk Drugs by Extractive Spectrophotometric Method

determination of sitagliptin phosphate in bulk drugs by extractive spectrophotometric method

Extractive Spectrophotometric Method for Determination of Carvedilol in Tablets

A sensitive and rapid extractive spectrophotometer method has been developed for the assay of carvedilol in pharmaceutical formulations. The method is based on the formation of a chloroform soluble ion-pair complex between carvedilol and bromocresol green in an acidic medium. The complex shows absorption maximum at 415 nm and the system obeys Beer’s law in the concentration range of 5-25 μg/ml....

Extractive spectrophotometric determination of ambrisentan.

PURPOSE Ambrisentan (ABS) is an antihypertensive drug used in the treatment of pulmonary atrial hypertension. The survey of literature for ABS revealed only two spectrophotometric methods for its quantification. The reported methods lack the sensitivity. This study is aimed at developing two sensitive extractive spectrophotometric methods for the determination of ABS in bulk and in tablets. M...

Extractive Spectrophotometric Method for the Determination of Tropicamide

Two simple, rapid, and extractive spectrophotometric methods were developed for the determination of tropicamide (TPC). These methods are based on the formation of ionpair complexes between the basic nitrogen of the drug with bromocresol purple (BCP) and methyl orange (MO) in acidic buffer solution. The formed complexes were extracted with chloroform and measured at 408 and 427 nm using BCP and...

Extractive Spectrophotometric Determination of Nisoldipine by Ion-pair Complex Formation

Nisoldipine, a 1-4-dihydropyridine drug is determined by the development of simple and sensitive Extractive Spectrophotometric method. In the present study an ion-pair complex of amino derivative of the Nisoldipine with Bromocresol Green Solution in acidic medium is formed with subsequent extraction of the ion-pair complex in Chloroform. Maximum absorption was seen at the wavelength of 418 nm t...

Spectrophotometric Methods for the Determination of Sitagliptin and Vildagliptin in Bulk and Dosage Forms

Simple, accurate and precise spectrophotometric methods have been developed for the determination of sitagliptin and vildagliptin in bulk and dosage forms. The proposed methods are based on the charge transfer complexes of sitagliptin phosphate and vildagliptin with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ), 7,7,8,8-tetracyanoquinodimethane (TCNQ) and tetrachloro-1,4-benzoquinone (p-chlor...